A single diethylcarbamazine dose for treatment of Wuchereria bancrofti carriers in French Polynesia: efficacy and side effects.
Identifieur interne : 00DA74 ( Main/Exploration ); précédent : 00DA73; suivant : 00DA75A single diethylcarbamazine dose for treatment of Wuchereria bancrofti carriers in French Polynesia: efficacy and side effects.
Auteurs : J L Cartel [Polynésie française] ; P. Celerier ; A. Spiegel ; C. Burucoa ; J F RouxSource :
- The Southeast Asian journal of tropical medicine and public health [ 0125-1562 ] ; 1990.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Diéthylcarbamazine.
- effets indésirables : Diéthylcarbamazine.
- usage thérapeutique : Diéthylcarbamazine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Filariose lymphatique, Humains, Microfilaria, Mâle, Polynésie, Wuchereria bancrofti.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- chemical , adverse effects : Diethylcarbamazine.
- chemical , therapeutic use : Diethylcarbamazine.
- drug effects : Microfilariae.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Humans, Male, Middle Aged, Polynesia, Wuchereria bancrofti.
Abstract
In the fall of 1988, 14 Tahitian Wuchereria bancrofti carriers were treated by a single diethylcarbamazine (DEC) 3 mg/kg dose. Determination of blood microfilarial (mf) density was carried out on days 0, 7, 14, 30, 90 and 180 using the membrane filtration technique. Clinical signs and side effects were noted during the 3 days following treatment. Complete clearance of microfilaremia was observed in two carriers (negativation rate 14%). A decrease of mf density was noted in all of the 14 carriers, ranging from 35.2 to 99.2% (median 78.75%). The percentage decrease in mf density, determined for the whole group from the geometric mean of the 14 mf counts, was 86% by day 7 and reached 95% by day 180. Side effects were observed in 10 patients (71%) of whom 3 only were unable to perform usual activities for less than 24 hours. Though it induced an incomplete initial mf clearance, a single DEC 3 mg/kg dose was effective in reducing about 90% of the microfilaremia and in sustaining this reduction over a period of six months. Such long-term reduction (comparable to that observed in W. bancrofti carriers treated with a daily DEC 6 mg/kg dose during 12 days) is likely responsible for the consistent decrease of total mf counts observed in the Tahitian population which has been treated for years with single DEC doses given every six months.
PubMed: 2075489
Affiliations:
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Spiegel</name></author><author><name sortKey="Burucoa, C" sort="Burucoa, C" uniqKey="Burucoa C" first="C" last="Burucoa">C. Burucoa</name></author><author><name sortKey="Roux, J F" sort="Roux, J F" uniqKey="Roux J" first="J F" last="Roux">J F Roux</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2075489</idno><idno type="pmid">2075489</idno><idno type="wicri:Area/PubMed/Corpus">005D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D20</idno><idno type="wicri:Area/PubMed/Curation">005D20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005D20</idno><idno type="wicri:Area/PubMed/Checkpoint">005D20</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005D20</idno><idno type="wicri:Area/Ncbi/Merge">003D36</idno><idno type="wicri:Area/Ncbi/Curation">003D36</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D36</idno><idno type="wicri:doubleKey">0125-1562:1990:Cartel J:a:single:diethylcarbamazine</idno><idno type="wicri:Area/Main/Merge">00E682</idno><idno type="wicri:Area/Main/Curation">00DA74</idno><idno type="wicri:Area/Main/Exploration">00DA74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A single diethylcarbamazine dose for treatment of Wuchereria bancrofti carriers in French Polynesia: efficacy and side effects.</title><author><name sortKey="Cartel, J L" sort="Cartel, J L" uniqKey="Cartel J" first="J L" last="Cartel">J L Cartel</name><affiliation wicri:level="1"><nlm:affiliation>Institut Territorial de Recherches Médicales Louis Malardé, Tahiti, French Polynesia.</nlm:affiliation><country xml:lang="fr">Polynésie française</country><wicri:regionArea>Institut Territorial de Recherches Médicales Louis Malardé, Tahiti</wicri:regionArea><wicri:noRegion>Tahiti</wicri:noRegion></affiliation></author><author><name sortKey="Celerier, P" sort="Celerier, P" uniqKey="Celerier P" first="P" last="Celerier">P. Celerier</name></author><author><name sortKey="Spiegel, A" sort="Spiegel, A" uniqKey="Spiegel A" first="A" last="Spiegel">A. Spiegel</name></author><author><name sortKey="Burucoa, C" sort="Burucoa, C" uniqKey="Burucoa C" first="C" last="Burucoa">C. Burucoa</name></author><author><name sortKey="Roux, J F" sort="Roux, J F" uniqKey="Roux J" first="J F" last="Roux">J F Roux</name></author></analytic><series><title level="j">The Southeast Asian journal of tropical medicine and public health</title><idno type="ISSN">0125-1562</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (administration & dosage)</term><term>Diethylcarbamazine (adverse effects)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Humans</term><term>Male</term><term>Microfilariae (drug effects)</term><term>Middle Aged</term><term>Polynesia</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Diéthylcarbamazine (effets indésirables)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filariose lymphatique ()</term><term>Humains</term><term>Microfilaria ()</term><term>Mâle</term><term>Polynésie</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polynesia</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Filariose lymphatique</term><term>Humains</term><term>Microfilaria</term><term>Mâle</term><term>Polynésie</term><term>Wuchereria bancrofti</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the fall of 1988, 14 Tahitian Wuchereria bancrofti carriers were treated by a single diethylcarbamazine (DEC) 3 mg/kg dose. Determination of blood microfilarial (mf) density was carried out on days 0, 7, 14, 30, 90 and 180 using the membrane filtration technique. Clinical signs and side effects were noted during the 3 days following treatment. Complete clearance of microfilaremia was observed in two carriers (negativation rate 14%). A decrease of mf density was noted in all of the 14 carriers, ranging from 35.2 to 99.2% (median 78.75%). The percentage decrease in mf density, determined for the whole group from the geometric mean of the 14 mf counts, was 86% by day 7 and reached 95% by day 180. Side effects were observed in 10 patients (71%) of whom 3 only were unable to perform usual activities for less than 24 hours. Though it induced an incomplete initial mf clearance, a single DEC 3 mg/kg dose was effective in reducing about 90% of the microfilaremia and in sustaining this reduction over a period of six months. Such long-term reduction (comparable to that observed in W. bancrofti carriers treated with a daily DEC 6 mg/kg dose during 12 days) is likely responsible for the consistent decrease of total mf counts observed in the Tahitian population which has been treated for years with single DEC doses given every six months.</div></front></TEI><affiliations><list><country><li>Polynésie française</li></country></list><tree><noCountry><name sortKey="Burucoa, C" sort="Burucoa, C" uniqKey="Burucoa C" first="C" last="Burucoa">C. Burucoa</name><name sortKey="Celerier, P" sort="Celerier, P" uniqKey="Celerier P" first="P" last="Celerier">P. Celerier</name><name sortKey="Roux, J F" sort="Roux, J F" uniqKey="Roux J" first="J F" last="Roux">J F Roux</name><name sortKey="Spiegel, A" sort="Spiegel, A" uniqKey="Spiegel A" first="A" last="Spiegel">A. Spiegel</name></noCountry><country name="Polynésie française"><noRegion><name sortKey="Cartel, J L" sort="Cartel, J L" uniqKey="Cartel J" first="J L" last="Cartel">J L Cartel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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